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Browsing Auburn University Graduate School by Author "Kaddoumi, Amal"

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Amylin and pramlintide modulate γ-secretase activity and APP processing in lipid rafts 

Mousa, Youssef (2019-06-24)
The misfolded amyloid-β (Aβ) peptide is generated in higher amounts in Alzheimer’s disease (AD), making this peptide a clinical hallmark for AD. A major site to produce Aβ is the lipid rafts, which are integral part of the ...

The Blood-Brain Barrier as a Therapeutic Target for Alzheimer’s Disease and Related Disorders 

Al Rihani, Sweilem (2019-06-10)
The blood-brain barrier (BBB) is a highly selective and protective membrane that preserves brain homeostasis and prevents the free entry of chemicals, toxins and drugs to the brain. The BBB barrier function is primarily ...

Endothelium5-HT3A receptor as a function of Age, ApoE, and ADRD pathology 

AL-GHRAIYBAH, Nour Fadel Mahmoud (2026-04-20)  ETD File Embargoed
Alzheimer’s disease (AD) is the most common type of dementia, which is clinically characterized by cognitive and memory impairment. One of the major hallmarks of AD is the blood-brain barrier (BBB) dysfunction. The BBB is ...

The Evaluation of a Pilot Theory-Based Nutrition Intervention Promoting a Mediterranean diet for the Reduction of Cardiovascular Disease Risk Factors in a High-Risk Population of the Southeastern United States: The Healthy Hearts Program 

Willis, Amy (2018-11-30)
In the United States, Cardiovascular disease (CVD) is responsible for 25% of deaths among adults with morbidity rates highest in the southeastern region of the country. Despite studies showing adherence to a Mediterranean-style ...

Evaluation of the effect of metabolism and transporters on drug pharmacokinetics and pharmacodynamics using PBPK modeling 

Darakjian, Lucy (2020-05-14)
In the latest years, multiple types of computational models have been used extensively in drug development, with a massive growth of uses of physiologically-based pharmacokinetic (PBPK) modeling in fields associated with ...

The Repurposing of R-Etodolac for Cerebrovascular Dysfunction in ADRD: In Vitro and In Vivo Studies 

Al khalifa, Amer (2026-04-23)  ETD File Embargoed
Alzheimer’s disease (AD) is the most common type of dementia, defined as a progressive neurodegenerative disorder. AD is pathologically characterized by amyloid-β (Aβ) accumulation, tau hyperphosphorylation, blood–brain ...

Targeting Neuroinflammation as a Therapeutic Approach in Alzheimer’s Disease Mouse Model 

Abdallah, Ihab (2020-08-24)
Alzheimer's disease (AD) is a complex neurodegenerative disorder and the most common form of dementia that affects people in their middle age, in the case of familial cases, and the elderly causing significant losses to ...